abstract：:Schistosomiasis is an important neglected tropical disease caused by digenean helminth parasites of the genus Schistosoma. Schistosomes are unusual in that they are dioecious and the adult worms live in the blood system. MicroRNAs play crucial roles during gene regulation and are likely to be important in sex differen...

journal_title：PLoS neglected tropical diseases

authors： Marco A,Kozomara A,Hui JH,Emery AM,Rollinson D,Griffiths-Jones S,Ronshaugen M

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. METHODOLOGY:Cross-sectional interview data and stool s...

journal_title：PLoS neglected tropical diseases

authors： Riess H,Clowes P,Kroidl I,Kowuor DO,Nsojo A,Mangu C,Schüle SA,Mansmann U,Geldmacher C,Mhina S,Maboko L,Hoelscher M,Saathoff E

更新日期：2013-09-05 00:00:00

abstract：:The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts. What is less clear are the factors influencing the distribution of virus-specific lineages. Japanese encephalitis virus (JEV) is the most important eti...

journal_title：PLoS neglected tropical diseases

authors： Schuh AJ,Ward MJ,Brown AJ,Barrett AD

更新日期：2013-08-29 00:00:00

abstract：:Bat rabies is an emerging disease of public health significance in the Americas. The Caribbean island of Trinidad experiences periodic outbreaks within the livestock population. We performed molecular characterisation of Trinidad rabies virus (RABV) and used a Bayesian phylogeographic approach to investigate the exten...

journal_title：PLoS neglected tropical diseases

authors： Seetahal JF,Velasco-Villa A,Allicock OM,Adesiyun AA,Bissessar J,Amour K,Phillip-Hosein A,Marston DA,McElhinney LM,Shi M,Wharwood CA,Fooks AR,Carrington CV

更新日期：2013-08-22 00:00:00

abstract：BACKGROUND:Enteric fever, a systemic infection caused by the bacteria Salmonella Typhi and Salmonella Paratyphi A, is endemic in Kathmandu, Nepal. Previous work identified proximity to poor quality water sources as a community-level risk for infection. Here, we sought to examine individual-level risk factors related to...

journal_title：PLoS neglected tropical diseases

authors： Karkey A,Thompson CN,Tran Vu Thieu N,Dongol S,Le Thi Phuong T,Voong Vinh P,Arjyal A,Martin LB,Rondini S,Farrar JJ,Dolecek C,Basnyat B,Baker S

更新日期：2013-08-22 00:00:00

abstract：BACKGROUND:Current chemotherapy for Chagas disease is unsatisfactory due to its limited efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment discontinuation. Combined therapy is envisioned as an ideal approach since it may improve treatment efficacy whilst decreasing toxici...

journal_title：PLoS neglected tropical diseases

authors： Diniz Lde F,Urbina JA,de Andrade IM,Mazzeti AL,Martins TA,Caldas IS,Talvani A,Ribeiro I,Bahia MT

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:The range of the Asian tiger mosquito Aedes albopictus is expanding globally, raising the threat of emerging and re-emerging arbovirus transmission risks including dengue and chikungunya. Its detection in Papua New Guinea's (PNG) southern Fly River coastal region in 1988 and 1992 placed it 150 km from mainla...

journal_title：PLoS neglected tropical diseases

authors： Beebe NW,Ambrose L,Hill LA,Davis JB,Hapgood G,Cooper RD,Russell RC,Ritchie SA,Reimer LJ,Lobo NF,Syafruddin D,van den Hurk AF

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:Access to health care is a major requirement in improving health and fostering socioeconomic development. In the People's Republic of China (P.R. China), considerable changes have occurred in the social, economic, and health systems with a shift from a centrally planned to a socialist market economy. This br...

journal_title：PLoS neglected tropical diseases

authors： Balen J,Liu ZC,McManus DP,Raso G,Utzinger J,Xiao SY,Yu DB,Zhao ZY,Li YS

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune res...

journal_title：PLoS neglected tropical diseases

authors： Menino JF,Saraiva M,Gomes-Alves AG,Lobo-Silva D,Sturme M,Gomes-Rezende J,Saraiva AL,Goldman GH,Cunha C,Carvalho A,Romani L,Pedrosa J,Castro AG,Rodrigues F

更新日期：2013-07-25 00:00:00

abstract：BACKGROUND:In 2005, there were outbreaks of febrile polyarthritis due to Chikungunya virus (CHIKV) in the Comoros Islands. CHIKV then spread to other islands in the Indian Ocean: La Réunion, Mauritius, Seychelles and Madagascar. These outbreaks revealed the lack of surveillance and preparedness of Madagascar and other ...

journal_title：PLoS neglected tropical diseases

authors： Andriamandimby SF,Heraud JM,Randrianasolo L,Rafisandratantsoa JT,Andriamamonjy S,Richard V

更新日期：2013-07-25 00:00:00

abstract：BACKGROUND:Mycobacterium ulcerans (MU) is responsible for disfiguring skin lesions and is endemic on the Bellarine peninsula of southeastern Australia. Antibiotics have been shown to be highly effective in sterilizing lesions and preventing disease recurrences when used alone or in combination with surgery. Our practic...

journal_title：PLoS neglected tropical diseases

authors： Friedman ND,Athan E,Hughes AJ,Khajehnoori M,McDonald A,Callan P,Rahdon R,O'Brien DP

更新日期：2013-07-18 00:00:00

abstract：:Glossina (G.) spp. (Diptera: Glossinidae), known as tsetse flies, are vectors of African trypanosomes that cause sleeping sickness in humans and nagana in domestic livestock. Knowledge on tsetse distribution and accurate species identification help identify potential vector intervention sites. Morphological species id...

journal_title：PLoS neglected tropical diseases

authors： Hoppenheit A,Murugaiyan J,Bauer B,Steuber S,Clausen PH,Roesler U

更新日期：2013-07-11 00:00:00

abstract：:In French Guiana, from 1984 to 2011, 14 animal rabies cases and 1 human rabies case (2008) were diagnosed. In January 2011, vampire-bat attacks occurred in 2 isolated villages. In mid-January, a medical team from the Cayenne Centre for Anti-Rabies Treatment visited the sites to manage individuals potentially exposed t...

journal_title：PLoS neglected tropical diseases

authors： Berger F,Desplanches N,Baillargeaux S,Joubert M,Miller M,Ribadeau-Dumas F,Spiegel A,Bourhy H

更新日期：2013-06-27 00:00:00

abstract：OBJECTIVE:The aim of the study is to examine the spatiotemporal pattern of Japanese Encephalitis (JE) in mainland China during 2002-2010. Specific objectives of the study were to quantify the temporal variation in incidence of JE cases, to determine if clustering of JE cases exists, to detect high risk spatiotemporal c...

journal_title：PLoS neglected tropical diseases

authors： Wang LY,Zhang WY,Ding F,Hu WB,Soares Magalhaes RJ,Sun HL,Li YX,Zou W,Wang Y,Liu QY,Li SL,Yin WW,Huang LY,Clements AC,Bi P,Li CY

更新日期：2013-06-20 00:00:00

abstract：:Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After ...

journal_title：PLoS neglected tropical diseases

authors： El Baidouri F,Diancourt L,Berry V,Chevenet F,Pratlong F,Marty P,Ravel C

更新日期：2013-06-13 00:00:00

abstract：:The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characteristics make 8-oxoG a g...

journal_title：PLoS neglected tropical diseases

authors： Aguiar PH,Furtado C,Repolês BM,Ribeiro GA,Mendes IC,Peloso EF,Gadelha FR,Macedo AM,Franco GR,Pena SD,Teixeira SM,Vieira LQ,Guarneri AA,Andrade LO,Machado CR

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are responsible for a substantial health and economic burden, particularly to low-income societies. Quan...

journal_title：PLoS neglected tropical diseases

authors： Otero-Abad B,Torgerson PR

更新日期：2013-06-06 00:00:00

abstract：BACKGROUND:Chlamydia trachomatis is the etiological agent of trachoma the world's leading cause of infectious blindness. Here, we investigate whether protracted clearance of a primary infection in nonhuman primates is attributable to antigenic variation or related to the maturation of the anti-chlamydial humoral immune...

journal_title：PLoS neglected tropical diseases

authors： Kari L,Bakios LE,Goheen MM,Bess LN,Watkins HS,Southern TR,Song L,Whitmire WM,Olivares-Zavaleta N,Caldwell HD

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:Antibody-detecting rapid diagnostic tests (RDTs) against rK39 are available to aid in the diagnosis of visceral leishmaniasis (VL). Although these rK39 RDTs have been developed, validated and approved for use with serum, they are universally performed using whole blood. It was therefore necessary to determin...

journal_title：PLoS neglected tropical diseases

authors： Matlashewski G,Das VN,Pandey K,Singh D,Das S,Ghosh AK,Pandey RN,Das P

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:Schistosoma mansoni and Schistosoma japonicum are the most frequent causative agents of human intestinal schistosomiasis. Approximately 200 million people in the world are infected with schistosomes. Diagnosis of schistosomiasis is often difficult. High percentages of low level infections are missed in routi...

journal_title：PLoS neglected tropical diseases

authors： Karl S,Gutiérrez L,Lucyk-Maurer R,Kerr R,Candido RR,Toh SQ,Saunders M,Shaw JA,Suvorova A,Hofmann A,House MJ,Woodward RC,Graeff-Teixera C,St Pierre TG,Jones MK

更新日期：2013-05-16 00:00:00

abstract：:Infection with the intracellular protozoan parasite Leishmania mexicana causes chronic disease in C57BL/6 mice, in which cutaneous lesions persist for many months with high parasite burdens (10(7)-10(8) parasites). This chronic disease process requires host IL-10 and FcγRIII. When Leishmania amastigotes are released f...

journal_title：PLoS neglected tropical diseases

authors： Buxbaum LU

更新日期：2013-05-09 00:00:00

abstract：OBJECTIVE:We conducted a systematic literature review with indirect comparison of studies evaluating therapeutic efficacy and toxicity associated to visceral leishmaniasis (VL) therapy among HIV infected individuals. MAIN OUTCOME MEASUREMENTS:The outcomes of interest were clinical and parasitological cure, mortality, ...

journal_title：PLoS neglected tropical diseases

authors： Cota GF,de Sousa MR,Fereguetti TO,Rabello A

更新日期：2013-05-02 00:00:00

abstract：:Leishmaniasis is a neglected disease produced by the intracellular protozoan parasite Leishmania. In the present study, we show that LABCG2, a new ATP-binding cassette half-transporter (ABCG subfamily) from Leishmania, is involved in parasite virulence. Down-regulation of LABCG2 function upon expression of an inactive...

journal_title：PLoS neglected tropical diseases

authors： Campos-Salinas J,León-Guerrero D,González-Rey E,Delgado M,Castanys S,Pérez-Victoria JM,Gamarro F

更新日期：2013-04-25 00:00:00

abstract：BACKGROUND:The frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents. Intense local pain is the major symptom reported after bites of P. nigriventer, although the mechanisms involved are sti...

journal_title：PLoS neglected tropical diseases

authors： Gewehr C,Oliveira SM,Rossato MF,Trevisan G,Dalmolin GD,Rigo FK,de Castro Júnior CJ,Cordeiro MN,Ferreira J,Gomez MV

更新日期：2013-04-25 00:00:00

abstract：:Japanese encephalitis virus (JEV) is a mosquito-borne, zoonotic flavivirus causing encephalitis in humans and reproductive disorder in pigs. JEV is present in large parts of Asia, where urbanization is high. Households within and outside Can Tho city, South Vietnam, were selected to monitor circulation of JEV. A neste...

journal_title：PLoS neglected tropical diseases

authors： Lindahl JF,Ståhl K,Chirico J,Boqvist S,Thu HT,Magnusson U

更新日期：2013-04-04 00:00:00

abstract：:Revealing the patterns and determinants of the spread of dengue virus (DENV) at local scales is central to understanding the epidemiology and evolution of this major human pathogen. We performed a phylogenetic analysis of the envelope (E) genes of DENV-1, -2, -3, and -4 isolates (involving 97, 23, 5, and 74 newly coll...

journal_title：PLoS neglected tropical diseases

authors： Rabaa MA,Klungthong C,Yoon IK,Holmes EC,Chinnawirotpisan P,Thaisomboonsuk B,Srikiatkhachorn A,Rothman AL,Tannitisupawong D,Aldstadt J,Nisalak A,Mammen MP,Gibbons RV,Endy TP,Fansiri T,Scott TW,Jarman RG

更新日期：2013-01-01 00:00:00

abstract：:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious blinding disease worldwide. Chronic conjunctival inflammation develops in childhood and leads to eyelid scarring and blindness in adulthood. The immune response to Ct provides only partial protection against re-infection, which can be frequent. ...

journal_title：PLoS neglected tropical diseases

authors： Hu VH,Holland MJ,Burton MJ

更新日期：2013-01-01 00:00:00

abstract：:Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Par...

journal_title：PLoS neglected tropical diseases

authors： de Léséleuc L,Orlova M,Cobat A,Girard M,Huong NT,Ba NN,Thuc NV,Truman R,Spencer JS,Adams L,Thai VH,Alcais A,Schurr E

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Aedes aegypti, the yellow fever mosquito, is an efficient vector of arboviruses and a convenient model system for laboratory research. Extensive linkage mapping of morphological and molecular markers localized a number of quantitative trait loci (QTLs) related to the mosquito's ability to transmit various pa...

journal_title：PLoS neglected tropical diseases

authors： Timoshevskiy VA,Severson DW,Debruyn BS,Black WC,Sharakhov IV,Sharakhova MV

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:In Latin America, there are 13 geographically isolated endemic foci distributed among Mexico, Guatemala, Colombia, Venezuela, Brazil and Ecuador. The communities of the three endemic foci found within Mexico have been receiving ivermectin treatment since 1989. In this study, we predicted the trend of occurre...

journal_title：PLoS neglected tropical diseases

authors： Lara-Ramírez EE,Rodríguez-Pérez MA,Pérez-Rodríguez MA,Adeleke MA,Orozco-Algarra ME,Arrendondo-Jiménez JI,Guo X

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The diagnosis of canine echinococcosis can be a challenge in surveillance studies because there is no perfect gold standard that can be used routinely. However, unknown test specificities and sensitivities can be overcome using latent-class analysis with appropriate data. METHODOLOGY:We utilised a set of fa...

journal_title：PLoS neglected tropical diseases

authors： Hartnack S,Budke CM,Craig PS,Jiamin Q,Boufana B,Campos-Ponce M,Torgerson PR

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:In Africa, relapsing fever borreliae are neglected arthropod-borne pathogens causing mild to deadly septicemia and miscarriage. The closely related Borrelia crocidurae, Borrelia duttonii, Borrelia recurrentis and Borrelia hispanica are rarely diagnosed at the species level, hampering refined epidemiological ...

journal_title：PLoS neglected tropical diseases

authors： Elbir H,Henry M,Diatta G,Mediannikov O,Sokhna C,Tall A,Socolovschi C,Cutler SJ,Bilcha KD,Ali J,Campelo D,Barker SC,Raoult D,Drancourt M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Worldwide, an estimated 30 to 100 million people are infected with Strongyloides stercoralis, a soil-transmitted helminth. Information on the parasite is scarce in most settings. In semi-rural Cambodia, we determined infection rates and risk factors; compared two diagnostic methods (Koga agar plate [KAP] cul...

journal_title：PLoS neglected tropical diseases

authors： Khieu V,Schär F,Marti H,Sayasone S,Duong S,Muth S,Odermatt P

更新日期：2013-01-01 00:00:00

abstract：:Yellow fever virus (YFV) is a mosquito-borne flavivirus that is a major public health problem in tropical areas of Africa and South America. There have been detailed studies on YFV ecology in West Africa and South America, but current understanding of YFV circulation on the African continent is incomplete. This inadeq...

journal_title：PLoS neglected tropical diseases

authors： Beck A,Guzman H,Li L,Ellis B,Tesh RB,Barrett AD

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Taenia solium cysticercosis/taeniosis is emerging as a serious public health and economic problem in many developing countries. This study was conducted to determine prevalence and risk factors of human T. solium infections in Mbeya Region, Tanzania. METHODS AND FINDINGS:A cross-sectional survey was conduct...

journal_title：PLoS neglected tropical diseases

authors： Mwanjali G,Kihamia C,Kakoko DV,Lekule F,Ngowi H,Johansen MV,Thamsborg SM,Willingham AL 3rd

更新日期：2013-01-01 00:00:00

abstract：:Over two-thirds of the world's population lives in regions where rabies is endemic, resulting in over 15 million people receiving multi-dose post-exposure prophylaxis (PEP) and over 55,000 deaths per year globally. A major goal in rabies virus (RABV) research is to develop a single-dose PEP that would simplify vaccina...

journal_title：PLoS neglected tropical diseases

authors： Dorfmeier CL,Tzvetkov EP,Gatt A,McGettigan JP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei, a Tier 1 Select Agent and the cause of melioidosis, is a Gram-negative bacillus present in the environment in many tropical countries. Defining the global pattern of B. pseudomallei distribution underpins efforts to prevent infection, and is dependent upon robust environmental samp...

journal_title：PLoS neglected tropical diseases

authors： Limmathurotsakul D,Dance DA,Wuthiekanun V,Kaestli M,Mayo M,Warner J,Wagner DM,Tuanyok A,Wertheim H,Yoke Cheng T,Mukhopadhyay C,Puthucheary S,Day NP,Steinmetz I,Currie BJ,Peacock SJ

更新日期：2013-01-01 00:00:00

abstract：:Schistosomes are intravascular helminths that infect over 200 million people worldwide. Deposition of eggs by adult schistosomes stimulates Th2 responses to egg antigens and induces granulomatous pathology that is a hallmark of schistosome infection. Paradoxically, schistosomes require host immune function for their d...

journal_title：PLoS neglected tropical diseases

authors： Ferragine CE,Walls CD,Davies SJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Wolbachia inherited intracellular bacteria can manipulate the reproduction of their insect hosts through cytoplasmic incompatibility (CI), and certain strains have also been shown to inhibit the replication or dissemination of viruses. Wolbachia strains also vary in their relative fitness effects on their ho...

journal_title：PLoS neglected tropical diseases

authors： Blagrove MS,Arias-Goeta C,Di Genua C,Failloux AB,Sinkins SP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The simian parasite Plasmodium knowlesi is a common cause of human malaria in Malaysian Borneo and threatens the prospect of malaria elimination. However, little is known about the emergence of P. knowlesi, particularly in Sabah. We reviewed Sabah Department of Health records to investigate the trend of each...

journal_title：PLoS neglected tropical diseases

authors： William T,Rahman HA,Jelip J,Ibrahim MY,Menon J,Grigg MJ,Yeo TW,Anstey NM,Barber BE

更新日期：2013-01-01 00:00:00